Portfolio Leader: Coronavirus Portfolio in the Drug Discovery Unit

Dundee University

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We are seeking a highly motivated and expert medicinal chemist for a key leadership role. The successful applicant will lead our coronavirus drug discovery programme, setting strategy, and ensuring goals and milestones are met. The appointee will lead, and drive interactions between the programme’s medicinal chemists, biologists, computational chemists and the drug metabolism & pharmacokinetics experts within the Drug Discovery Unit (DDU) team. The successful applicant will use organisational and scientific "know-how" to successfully manage the broad range of collaborations (with both industry and academia) required to progress a portfolio of hit and lead optimisation projects towards candidate nomination for pre-clinical development. They will oversee the appropriate accessing of the in vitro assays (biochemical, cell based and high content); secondary/ functional studies; toxicological screening (in vitro); chemistry outsourcing and animal models of disease required to support progression of a portfolio of small molecule drug discovery projects.

The DDU (see http://www.drugdiscovery.dundee.ac.uk) is a fully integrated drug discovery organisation based within a world class Life Sciences research environment. Its remit is to complement BioPharma activities by tackling both neglected diseases (e.g. leishmaniasis, TB and malaria) and validating novel drug targets across a range of therapeutics areas. The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The project goals will range from quality leads demonstrating disease model proof of concept, through to pre-clinical candidates.

The successful applicant will be required to report (verbally and written) on progress both internally, and to collaborators and funding agencies, and where required, will also be expected to co-ordinate drafting of patents with the University of Dundee Intellectual Property Office. Where opportunities exist, they will co-ordinate the writing of scientific publications and make presentations at external scientific conferences.

In addition to leading a project, they will contribute more widely to the DDU through wider leadership activities, helping to drive innovation within the drug discovery process and best practice.

It is envisaged that significant international travel will be required to fulfil this position.

The post is available for an immediate start. Salary will depend on experience but will be between £52,560 - £59,135.

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